Progesterone Capsules

Progesterone is the natural balancing hormone for estrogen. As women age, progesterone production declines — often earlier and more steeply than estrogen. After peaking around age 25, progesterone levels can drop by 50% by age 40 and continue declining through menopause.

This creates an imbalance known as "estrogen dominance," where estrogen's effects are no longer properly counterbalanced by progesterone.

Compounded progesterone uses bioidentical progesterone — chemically identical to the progesterone your body produces naturally.

Oral capsules are the most common form. We compound progesterone capsules in the following strengths:

• 25 mg
• 50 mg
• 100 mg
• 150 mg (modified-release)
• 200 mg
• 300 mg

Modified-release capsules release progesterone gradually and may be prescribed when a sustained effect is needed.

Topical cream is applied to the skin and absorbed transdermally. Available concentrations include 2%, 2.5%, 3%, 4%, 5%, and 6%. Topical progesterone avoids first-pass liver metabolism, which means more of the hormone reaches the bloodstream unchanged.

Vaginal suppositories (50 mg, 100 mg, 400 mg) may be prescribed for localized delivery, particularly in fertility support.

Your prescriber determines which form and strength is appropriate based on your symptoms, hormone levels, and treatment goals.

Progesterone replacement therapy can help address symptoms of estrogen dominance and low progesterone, including:

• Mood disturbances and irritability
• Insomnia and sleep difficulties
• Weight gain (particularly related to thyroid function disturbance)
• Headaches
• Difficulty concentrating
• Reduced sex drive
• Anxiety

Progesterone is also commonly prescribed alongside estrogen therapy to reduce the risk of endometrial issues associated with unopposed estrogen use.

Oral capsules are taken by mouth, typically at bedtime. Oral progesterone undergoes first-pass metabolism in the liver, producing metabolites that may have a mild calming effect — which is why bedtime dosing is common.

Topical cream is applied to the skin (inner arm, inner thigh, or as directed). Because it bypasses the liver, a larger proportion of the progesterone reaches the bloodstream. Some prescribers prefer topical delivery when specific blood levels are targeted.

Both forms use the same bioidentical progesterone. The choice between them depends on your prescriber's assessment of your symptoms, hormone levels, and how your body responds.

Capsules: Take by mouth as directed, usually at bedtime. Swallow whole — do not open, crush, or chew.

Topical cream:

1. Apply the prescribed amount to clean skin (inner arm, inner thigh, or behind the knees)
2. Rotate application sites to avoid skin irritation
3. Rub in gently until the cream is absorbed
4. Wash hands after application
5. Avoid skin-to-skin contact with others at the application site

• Store capsules and cream at room temperature
• Avoid extreme heat, cold, and direct sunlight
• Keep away from moisture (do not store in a bathroom)
• Check the beyond-use date on the label