Diazepam Vaginal Suppository

Diazepam is a benzodiazepine medication that enhances the effects of GABA — the body's main inhibitory neurotransmitter. GABA reduces nerve excitability and has sedating, anti-anxiety, and muscle-relaxant properties.

When formulated as a vaginal suppository, diazepam delivers its muscle-relaxing effects directly to the pelvic floor muscles where they are most needed.

Diazepam suppositories are used to treat high-tone pelvic floor dysfunction, also known as:

• Hypertonic pelvic floor dysfunction
• Non-relaxing pelvic floor dysfunction
• Pelvic muscle spasms

In this context, "high tone" refers to muscles that are in a constant state of contraction — rigid and unable to relax. This causes chronic pain and discomfort, and can result in sexual pain.

A 2010 study by Rogalski et al. found that vaginal diazepam suppositories gave a clinically significant improvement when added to standard treatments (pelvic physical therapy and trigger point injections).

Potential side effects include:

• Drowsiness
• Local vaginal irritation
• Dizziness or headache
• Lack of coordination
• Problems falling or staying asleep

Report any side effects to your pharmacist or prescriber.

Use exactly as directed on the prescription label. Diazepam vaginal suppositories are usually inserted vaginally, often at bedtime when prescribed that way.

• Wash hands before and after use
• Insert the suppository as directed by the label or care team
• Because diazepam can cause drowsiness or impaired coordination, avoid driving, alcohol, cannabis, or other sedating medications unless your prescriber has reviewed the plan
• Call the pharmacy or prescriber if sedation, dizziness, worsening pain, irritation, or unusual symptoms occur