Hydroquinone Cream

Hydroquinone (HQ) is one of the most effective inhibitors of melanogenesis (melanin production). When applied topically, it causes a reversible depigmentation of the skin by blocking the enzyme tyrosinase and reducing melanocyte metabolic processes.

Hydroquinone is used to treat skin hyperpigmentation including:

• Melasma
• Chloasma
• Freckles and age spots (senile lentigines)
• Post-burn hyperpigmentation
• Post-inflammatory hyperpigmentation

Results typically begin to appear after about 4 weeks, with full benefits taking up to 3 months or more.

Hydroquinone produces depigmentation through several mechanisms:

• Blocking the enzyme tyrosinase, preventing melanin formation
• Reducing melanocyte metabolic processes
• Decreasing melanosome production and altering their internal structure
• Increasing the breakdown of melanosomes

To improve effectiveness, hydroquinone can be combined with other ingredients such as tretinoin, glycolic acid, fluocinolone, kojic acid, hydrocortisone, or ascorbic acid.

Possible side effects include:

• Skin sensitivity or redness
• Drying and flaking
• Allergic reactions (rare)

Precautions:

• Test a small amount on healthy skin first and observe for 24 hours
• Use sunscreen and avoid excessive sun exposure to prevent repigmentation
• Compounded hydroquinone cream should be refrigerated
• Safety in pregnancy is not well established — use only if directed by your physician